It is important to use cefaclor for the full course of treatment. Failure to do so may decrease the effectiveness of this treatment and may increase the risk that the bacteria will no longer be sensitive to cefaclor and it will not be able to be treated by this or certain other antibiotics in the future. Patients should be counseled that antibacterial drugs including Cefaclor for Oral Suspension should only be used to treat bacterial infections. When cefaclor is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may 1 decrease the effectiveness of the immediate treatment and 2 increase the likelihood that bacteria will develop resistance and will not be treatable by cefaclor or other antibacterial drugs in the future. Diarrhea is a common problem caused by antibiotecs which usually ends when the antibiotic is discontinued. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools with or without stomach cramps and fever even as late as two or more months after having taken the last dose of the antibiotic. If this occurs, patients should contact their physician as soon as possible. lowest price eprex
When available, the clinical microbiology laboratory should provide the result of in vitro susceptibility test results for antimicrobial drugs used in resident hospitals to the physician as periodic reports that describe the susceptibility profile of nosocomial and community-acquired pathogens. These reports should aid the physician in selecting an antibacterial drug for treatment. Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure as required. Studies have not been performed to determine potential for carcinogenicity, mutagenicity, or impairment of fertility.
Abnormal skin sensations; anal itching; difficulty breathing; fainting; fluid retention; flushing; headache; joint pain and inflammation; low blood pressure; mild diarrhea; nausea; secondary fungal infections, particularly of the oral, rectal, vaginal, and intestinal areas; sinus infection; skin redness; tiredness; vomiting; weakness. Skin and skin structure infections, uncomplicated: Treatment of uncomplicated skin and skin structure infections due to Staphylococcus aureus methicillin-susceptible or S. pyogenes capsules and oral suspension only. NOTE: In view of the insufficient numbers of isolates of ß-lactamase-producing strains of Haemophilus influenzae that were obtained from clinical trials with cefaclor extended-release tablets for patients with acute bacterial exacerbations of chronic bronchitis or secondary bacterial infections of acute bronchitis, it was not possible to adequately evaluate the effectiveness of cefaclor extended-release tablets for bronchitis known, suspected, or considered potentially to be caused by ß-lactamase-producing H. influenzae.
Avadel Pharmaceuticals USA Inc. Ninth Edition. CLSI document M07-A9, Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, 2012. 2. Clinical and Laboratory Standards Institute CLSI. Patients should be counseled that antibacterial drugs including cefaclor extended-release tablets USP should only be used to treat bacterial infections.
Cefaclor has been shown to be active against most strains of the following microorganisms, both in vitro and in clinical infections as described in the INDICATIONS AND USAGE section. Symptoms may include diarrhea, nausea, stomach pain, and vomiting. Do not use extra medicine to make up the missed dose. CDAD. Hypertoxin producing strains of C. difficile cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require colectomy. CDAD must be considered in all patients who present with diarrhea following antibiotic use. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents. For the best possible benefit, it is important to receive each scheduled dose of this as directed. If you miss a dose, contact your doctor or right away to establish a new dosing schedule. Be sure to use cefaclor capsules for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future. This medication can cause you to have unusual results with certain medical tests. Other effects considered related to therapy included eosinophilia 1 in 50 patients genital pruritus, moniliasis or vaginitis about 1 in 50 patients and, rarely, thrombocytopenia or reversible interstitial nephritis. CDAD. Hypertoxin- producing strains of C. difficile cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require colectomy. CDAD must be considered in all patients who present with diarrhea following antibiotic use. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents. As with other cephalosporins, the bactericidal action of cefaclor results from inhibition of cell-wall synthesis.
In the treatment of β-hemolytic streptococcal infections, a therapeutic dosage of cefaclor should be administered for at least 10 days. BCG Intravesical: Antibiotics may diminish the therapeutic effect of BCG Intravesical. In adequate and well-controlled clinical trials of cefaclor extended-release tablets in the treatment of acute bacterial exacerbations of chronic bronchitis ABECB and secondary bacterial infections of acute bronchitis SBIAB only 4 evaluable patients with ABECB and no evaluable patients with SBIAB had infections caused by ß-lactamase-producing H. influenzae. Four patients do not provide adequate data upon which to judge clinical efficacy of cefaclor extended-release tablets against ß-lactamase-producing H. influenzae. Resistance to Cefaclor is primarily through hydrolysis of beta-lactamases, alteration of penicillin-binding proteins PBPs and decreased permeability. Pseudomonas spp. Phenylketonuria patients - Cefaclor contains phenylalanine. Use cefaclor capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions. Clostridium difficile associated diarrhea CDAD has been reported with use of nearly all antibacterial agents, including Cefaclor for Oral Suspension, USP, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. difficile. Cefaclor is moderately dialyzable 20% to 30% reduction in half-life. Cephalosporins as a class have been associated with false-positive tests for urine glucose. Black, hairy tongue; irritation of the mouth or throat; mild diarrhea; nausea; upset stomach; vomiting. The following in vitro data are available, but their clinical significance is unknown. At least 90 percent of the following bacteria exhibit an in vitro minimum inhibitory concentrations MICs less than or equal to the susceptible breakpoint of Cefaclor. However, the safety and effectiveness of Cefaclor in treating clinical infections due to these bacteria has not been established in adequate and well-controlled trials. Occasionally, solitary symptoms may occur, but do not represent a serum-sickness-like reaction. While further investigation is ongoing, serum-sickness-like reactions appear to be due to hypersensitivity and more often occur during or following a second or subsequent course of therapy with Cefaclor. Symptoms of pseudomembranous colitis may appear either during or after antibiotic treatment. See WARNINGS. arcoxia
Antibiotics work best when the amount of medicine in your body is kept at a constant level. Therefore, take this drug at evenly spaced intervals. Appropriate culture and susceptibility studies should be performed to determine susceptibility of the causative organism to Cefaclor. Long-term or repeated use of cefaclor may cause a second infection. Your doctor may want to change your medicine to treat the second infection. Contact your doctor if signs of a second infection occur. As has also been reported with other β-lactam antibiotics, transient lymphocytosis, leukopenia, and, rarely, hemolytic anemia, aplastic anemia, agranulocytosis, and reversible neutropenia of possible clinical significance. Quenzer RW, Davis RL, Neidhart MM "Prospective randomized study comparing the efficacy and safety of ciprofloxacin with cefaclor in the treatment of patients with purulent bronchitis. how to order naproxen uk naproxen
When cefaclor extended-release tablets are taken with food, the AUC is 10% lower while the C max is 12% lower and occurs 1 hour later compared to cefaclor immediate-release capsules. Clinical and Laboratory Standards Institute CLSI. Performance Standards for Antimicrobial Disk Diffusion Susceptibility Tests; Approved Standard- Twelth Edition. CLSI document M02-A12, Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, 2015. Appropriate culture and susceptibility studies should be performed to determine susceptibility of the causative organism to cefaclor. Genitourinary side effects have included genital pruritus and vaginitis in less than 1% of patients. Rarely, reversible hyperactivity, agitation, nervousness, insomnia, confusion, hypertonia, dizziness, hallucinations, and somnolence have been reported. Cefaclor MR is well absorbed from the gastro-intestinal tract. Filipe P, Almeida RSLS, Rodrigo FG "Occupational allergic contact dermatitis from cephalosporins. Continue to take this medication until the full-prescribed amount is finished even if symptoms disappear after a few days. Stopping this medication too early may allow bacteria to continue to grow, which may result in a relapse of the infection. Efficacy of the extended-release formulation has not been established for the treatment of skin and soft tissue infections due to Streptococcus pyogenes. If you have any questions about cefaclor, please talk with your doctor, pharmacist, or other health care provider. Antacids may decrease the absorption of this medication. If you use antacids, take them at least 1 hour apart from this drug. Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools with or without stomach cramps and fever even as late as two or more months after having taken the last dose of the antibiotic. If this occurs, patients should contact their physician as soon as possible. Cefaclor Capsules, USP 250 mg: opaque purple and white hard gelatin capsules imprinted with “West-ward 985” in bottles of 15 and bottles of 100. Do not stop taking any medications without consulting your healthcare provider. Hormonal birth control eg, birth control pills may not work as well while you are using Penicillin-VK. To prevent pregnancy, use an extra form of birth control eg, condoms. purchase demadex wikipedia
Not all side effects for cefaclor may be reported. You should always consult a doctor or healthcare professional for medical advice. This information should not be used to decide whether or not to take cefaclor or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about cefaclor. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to cefaclor. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using cefaclor. Some MEDICINES MAY INTERACT with Penicillin-VK. Note: Penicillin is the usual drug of choice in the treatment and prevention of streptococcal infections, including the prophylaxis of rheumatic fever. Cefaclor is generally effective in the eradication of streptococci from the nasopharynx; however, substantial data establishing the efficacy of Cefaclor in the subsequent prevention of rheumatic fever are not available at present. Cefaclor Capsules, USP are a semisynthetic cephalosporin antibiotic for oral administration. It is chemically designated as 3-chloro-7-D-2-phenylglycinamido-3-cephem-4-carboxylic acid monohydrate. The toxic symptoms following an overdose of cefaclor may include nausea, vomiting, epigastric distress, and diarrhea. The severity of the epigastric distress and the diarrhea are dose related. If other symptoms are present, it is probable that they are secondary to an underlying disease state, an allergic reaction, or the effects of other intoxication. Secondary bacterial infections of acute bronchitis due to Haemophilus influenzae excluding ß-lactamase-negative, ampicillin-resistant strains Moraxella catarrhalis, or Streptococcus pneumoniae. See above NOTE. This drug may make you dizzy. not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit beverages. Cefaclor has been shown to be active against most strains of the following microorganisms both in vitro and in clinical infections as described in the section. Superinfection overgrowth by non-susceptible organisms should always be considered a possibility in a patient being treated with a broad spectrum antimicrobial. Careful observation of the patient is essential. If superinfection occurs during therapy, appropriate measures should be taken. Prescribing Cefaclor in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increase the risk of the development of drug-resistant bacteria. Supplement. CLSI document M100-S25. what does generic erythromycin pill look like erythromycin
Cefaclor extended-release tablets USP, 500 mg based on the anhydrous are available as film-coated, oval-shaped, unscored, dark blue tablets, debossed with “93” on one side and “1087” on the other side. They are available in bottles of 100. Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment See . Nausea and vomiting have been reported rarely. As with some penicillins and some other cephalosporins, transient hepatitis and cholestatic jaundice have been reported rarely. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. NOTE: Only penicillin by the intramuscular route of administration has been shown to be effective in the prophylaxis of rheumatic fever. Cefaclor extended-release tablets are generally effective in the eradication of S. pyogenes from the oropharynx; however, data establishing the efficacy of cefaclor extended-release tablets for the prophylaxis of subsequent rheumatic fever are not available. Chew thoroughly before swallowing. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Cefaclor extended-release tablets are contraindicated in patients with known hypersensitivity to cefaclor and other cephalosporins. Some cephalosporins have been associated with seizures, primarily when dosages were not reduced in renally impaired patients. Prescribing cefaclor in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria. Prolonged use of cefaclor may result in the overgrowth of nonsusceptible organisms. Careful observation of the patient is essential. If superinfection occurs during therapy, appropriate measures should be taken. Positive direct Coombs' tests have been reported during treatment with the cephalosporin antibiotics.
Small amounts of Cefaclor have been detected in mother's milk following administration of single 500 mg doses. Drug information contained herein may be time sensitive. Of the 3703 patients in clinical studies of cefaclor, 594 16. If any of these effects last or get worse, tell your doctor or promptly. Diabetes patients - Cefaclor may cause false test results with some urine glucose tests. Check with your doctor before you adjust the dose of your diabetes medicine or change your diet. ragol.info progesterone
Store cefaclor capsules at room temperature, 59 to 86 degrees F 15 to 30 degrees C in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep cefaclor capsules out of the reach of children and away from pets. Some MEDICINES MAY INTERACT with cefaclor capsules. Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea pseudomembranous colitis may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor. If you are using this medication at home, learn all preparation and usage instructions from your professional. Before using, check this product visually for particles or discoloration. If either is present, not use the liquid. Cefaclor MR during the controlled clinical trials. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Cefaclor for Oral Suspension and other antibacterial drugs, Cefaclor for Oral Suspension should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Positive direct Coombs', false-positive urinary glucose test using cupric sulfate Benedict's solution, Clinitest, Fehling's solution. Absorption of drugs from the gastrointestinal tract may be decreased by giving activated charcoal, which, in many cases, is more effective than emesis or lavage. Consider charcoal instead of or in addition to gastric emptying. Repeated doses of charcoal over time may hasten elimination of some drugs that have been absorbed. purchase aristocort royal
Other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out. Overdose symptoms may include nausea, vomiting, stomach pain, and diarrhea. Trace amounts were detected at 1 hour. The effect on nursing infants is not known. Caution should be exercised when cefaclor is administered to a nursing woman. Pommer W, Krause PH, Berg PA, et al "Acute interstitial nephritis and non-oliguric renal failure after cefaclor treatment. Cefaclor may be administered in the presence of impaired renal function. zyvox
Before using this medication, tell your doctor or pharmacist your medical history. Many people using this medication not have serious side effects. Staphylococcus epidermidis including beta-lactamase producing strains. IF AN ALLERGIC REACTION TO CEFACLOR OCCURS, DISCONTINUE THE DRUG. SERIOUS ACUTE HYPERSENSITIVITY REACTIONS MAY REQUIRE TREATMENT WITH EPINEPHRINE AND OTHER EMERGENCY MEASURES, INCLUDING OXYGEN, INTRAVENOUS FLUIDS, INTRAVENOUS ANTIHISTAMINES, CORTICOSTEROIDS, PRESSOR AMINES, AND AIRWAY MANAGEMENT, AS CLINICALLY INDICATED. Proteus mirabilis and Staphylococcus saprophyticus. Christensen JC, Swenson E, Gooch WM, Herrod JN "Comparative efficacy and safety of cefprozil BMY-28100 and cefaclor in the treatment of acute group A beta-hemolytic streptococcal pharyngitis. Cefaclor should be administered for at least 10 days when treating beta-hemolytic streptococcal infections. This could be a symptom of a serious side effect requiring immediate medical attention. Do not treat diarrhea without consulting your doctor. This is given by injection into a vein as directed by your doctor, usually once a day over 1 hour. The dosage and length of treatment are based on your medical condition, response to treatment, and other you may be taking. The following in vitro data are available, but their clinical significance is unknown. At least 90 percent of the following bacteria exhibit an in vitro minimum inhibitory concentrations MICs less than or equal to the susceptible breakpoint of cefaclor. Lower urinary tract infections: 375mg twice daily or 500mg once daily. Twelfth Edition. CLSI document M02-A12, Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, 2015. If you are using this medication at home, learn all preparation and usage instructions from your professional. Before using, check the product visually for particles or discoloration. If either is present, not use the liquid. Learn how to store and discard medical supplies safely. It works by stopping the growth of bacteria. In those requiring hospitalization, the symptoms have ranged from mild to severe at the time of admission with more of the severe reactions occurring in pediatric patients. Antihistamines and glucocorticoids appear to enhance resolution of the signs and symptoms. No serious sequelae have been reported. seroquel
Yung Shin Pharmaceutical Ind. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. This is given by injection into a vein as directed by your doctor, usually every 8 or 12 hours. The dosage is based on your medical condition and response to treatment. NOTE: The extent of absorption AUC of cefaclor from cefaclor immediate-release capsules is unaffected by food intake; however, when cefaclor immediate-release capsules are taken with food, the C max is decreased. Use Penicillin-VK as directed by your doctor. Check the label on the medicine for exact dosing instructions. Signs and symptoms usually occur a few days after initiation of therapy and subside within a few days after cessation of therapy. General management consists of supportive therapy. Note: Not a preferred drug Shulman 2012. Cefaclor capsules are to be used only by the patient for whom it is prescribed. Do not share it with other people. In elderly subjects over age 65 with normal serum creatinine values, higher peak plasma concentrations and AUCs have been observed. This is considered to be primarily a result of an age-related decrement in renal function, and has no apparent clinical significance. Therefore, dosage adjustment is not necessary in elderly subjects with normal serum creatinine values. Acinetobacter calcoaceticus and most strains of Enterococi Enterococcus faecalis, group D streptococci Enterobacter spp. Important: The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, blogs, or WebMD Answers are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. The toxic symptoms following an overdose of cefaclor may include nausea, vomiting, epigastric distress, and diarrhea. The severity of the epigastric distress and the diarrhea are dose-related. The absorption of cefaclor extended-release is enhanced when it is administered with food. Get emergency medical help if you have signs of an allergic reaction: hives, numbness or tingling; weakness, feeling light-headed; difficult breathing; swelling of your face, lips, tongue, or throat.
Multum Information Services, Inc. Peritoneal dialysis: Administer 250 to 500 mg every 8 hours. Discuss specific use of drug and side effects with patient as it relates to treatment. HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Aminoglycosides: Cephalosporins 2nd Generation may enhance the nephrotoxic effect of Aminoglycosides. Take Penicillin-VK by mouth. Penicillin-VK is best absorbed when taken on an empty stomach 1 hour before or 2 hours after meals but may be taken with food. Note: β-lactamase-negative, ampicillin-resistant BLNAR strains of Haemophilus influenzae should be considered resistant to Cefaclor despite apparent in vitro susceptibility of some BLNAR strains. When cefaclor extended-release tablets USP are prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may 1 decrease the effectiveness of the immediate treatment and 2 increase the likelihood that bacteria will develop resistance and will not be treatable by cefaclor extended-release tablets USP or other antibacterial drugs in the future. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Penicillin-VK while you are pregnant. Penicillin-VK is found in breast milk. If you are or will be breast-feeding while you use Penicillin-VK, check with your doctor. Discuss any possible risks to your baby. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Hyslop DL "Cefaclor safety profile: a ten-year review. No overall differences in safety or effectiveness were observed between these subjects and younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out. This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your with you, and share the list with your doctor and pharmacist. Teriflunomide: May increase the serum concentration of OAT3 Substrates. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs. buy noroxin uk boots
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Forced diuresis, peritoneal dialysis, hemodialysis, or charcoal hemoperfusion have not been established as beneficial for an overdose of Cefaclor. Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Cefaclor will not treat a viral infection such as the flu or a common cold. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. ranexa money order australia
The color of the capsule powder is white to off white. Safety and effectiveness of cefaclor extended-release tablets in pediatric patients less than 16 years of age have not been established. Renal impairment: Use with caution in patients with renal impairment. Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Cefaclor extended-release tablets have been shown to be active against most strains of the following microorganisms both in vitro and in clinical infections as described in the INDICATIONS AND USAGE section. primperan
Clostridium difficile associated diarrhea CDAD has been reported with almost all antibiotics and may potentially be life-threatening. Therefore, it is important to consider this diagnosis in patients who present with diarrhea following cephalosporin therapy. Mild cases generally improve with discontinuation of the drug, while severe cases may require supportive therapy and treatment with an antimicrobial agent effective against C difficile. Hypertoxin producing strains of C difficile cause increased morbidity and mortality; these infections can be resistant to antimicrobial treatment and may necessitate colectomy.
Tell your doctor if you are before using this medication. Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment see . Nausea and vomiting have been reported rarely. As with some penicillins and some other cephalosporins, transient hepatitis and cholestatic jaundice have been reported rarely. One case report of acute interstitial nephritis and nonoliguric renal failure has been reported following cefaclor therapy. Reversible fever, azotemia, pyuria, and eosinophiluria are the hallmarks of cephalosporin-induced interstitial nephritis. If you miss a dose of cefaclor, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.